dear brightly night shift
woman using dear brightly night shift
night shift cream
night shift cream on hands
dear brightly night shift and night shift refill
dear brightly night shift set
night shift refill

Night Shift Trial

Tailored Retinoid

$66  $59.00
First Time Trial 2-month supply

  • First-time bottle lasts ~2 months. Refills last ~3 months and bill at $99/quarter. Change frequency or cancel anytime.
  • Bonus ingredient: Niacinamide, an anti-inflammatory healing compound that calms redness and boosts hydration.
  • Enjoy the ease of a doctor's consult online.
Free shipping

Get to know Night Shift

Night Shift is formulated with a powerful blend of Tretinoin, a prescription strength retinoid, and gentle, hydrating ingredients to transform your nightly skincare routine. Harnessing the dynamic duo of Tretinoin and Niacinamide, our tailored formula from skin experts is made for your unique skin. Our silky-smooth texture indulges your skin with every application.


    Trust the science. Your Tretinoin online prescription is proven to prevent and treat wrinkles, pigmentation, uneven skin tone, enlarged pores, and acne. Niacinamide is an anti-inflammatory healing compound that calms redness, reduces the appearance of big pores, prevents moisture loss and dehydration, and brightens the skin. Like every perfect match, they work together to reveal your best skin ever.

    Stimulates the production of collagen, improving the appearance of wrinkles and fine lines.

    Decreases comedones (small bumps) and their underlying causes, reducing both non-
    inflammatory and inflammatory acne.

    Clears cellular debris around enlarged pores, making them appear smaller.

    Improves roughness by reducing the layer of dead skin cells and increasing glycosoaminoglycan (GAG), which supports healthy elastin and collagen.

    Sun & Dark Spots
    Improves pigmentation of freckles, melasma, sunspots, and dark spots by dispersing melanin
    granules (your body’s built-in UV protection).

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    The Power of Retinoids


    Retinoid stimulates the production of collagen, softening the appearance of fine lines and wrinkles. They also boost new blood vessels, which can give you a youthful rosy glow.


    Yes! Retinoids clear cellular debris around enlarged pores, making them appear smaller and keeping them cleaner.


    Retinoids are a first-line defense for treating and preventing blackheads as they decrease comedones and their precursor, thereby decreasing non inflammatory and inflammatory acne.


    Tough acne that hasn’t responded to your usual treatments may respond well to a topical tretinoin prescription online. Retinoids unclog pores, which means your skin will absorb creams more efficiently.


    Since topical retinoids exfoliate the skin, they definitely aid in the natural elimination of milia. It also iImproves roughness by reducing the layer of dead skin cells and increasing glycosaminoglycan (GAG).

    Sun and Dark Spots

    While not a cure-all for every type of hyperpigmentation, anti-inflammatory topical retinoids can improve pigmentation of freckles, melasma, sun spots and dark spots by dispersing melanin granules.



    Depending on your skin profile evaluation, Tretinoin strengths range from 0.015% to .089%

    moisturizer close up hyaluronic acid derm grade retinoids


    An anti-inflammatory healing compound that calms redness and boosts hydration

    Base: ST-Elastomer 10, Q7-9120 Silicone Fluid, EL-7040 Hydro Elastomer Blend, Vitamin E Acetate, Liquid, Polyglycerol-3 Diisostearique

    All products are cruelty-free, paraben-free, mineral oil-free, and vegan.

    Cruelty Free

    Paraben Free

    Fragrance Free

    Alcohol Free

    Prescription-strength retinoids for your healthiest skin

    We offer a tailored solution from doctors online as easy as 1-2-3.

    woman adding dear brightly cream on her face

    Step 1

    Share your skin goals

    No need for an in-person visit to the
    dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.

    open night shit from packaging

    Step 2

    Our doctors tailor your formula

    You are unique and your skin is too. A doctor will review your profile and tailor your derm-strength Night Shift serum to create a formula just for you.

    using dear brightly

    Step 3

    Check in with your skin coach

    Like any fitness routine, retinoids work best by starting out slowly. Your provider is available at any time to check in and assess your progress.

    Take on the Night Shift

    The Dear Brightly guide to your retinoid. For nighttime use only. For best results, use consistently.

    gentle logo

    1. Cleanse

    Wash your face with a gentle cleanser, then dry completely

    happy logo

    2. Treat with Night Shift

    Apply only a pea-sized amount evenly to your face, including neck if desired.

    Start by using every third night, then gradually build to nightly as tolerated. Listen to your skin, it knows best.

    moisturizer logo

    3. Moisturize

    Follow up with your go-to moisturizer.

    Night Shift For Anyone And Everyone

    Are you a retinoid newbie?

    Board-certified doctors will get to know your skin and start you off with an appropriate strength level so that even if you’re new to a retinoid, your skin learns to tolerate it over time. And when they think you’re ready, they’ll upgrade your strength. They tailor your retinoid so that whether you’re a retinoid newbie or veteran, you get a great retinoid experience. 

    woman with brown hair
    woman with blonde hair
    Do you have sensitive or dry skin?

    After getting to know your skin, board-certified doctors can give you a better experience with tailored retinoids. From sensitive to resistant skin, whether you’re a retinoid rookie or not, they got you.  Understanding that every skin is different, they provide you with an appropriate strength level for your specific skin type. All of this is so that you get a great retinoid experience over time. 

    Start seeing results as early as 2 weeks*

    Practice makes progress! Start slowly, be patient, and watch your skin transform. Collagen isn’t built in a day, so we’ve made sure you’ve got the right routine for the journey. And we’re here to be your coach, teammate, and biggest fan – every step of the way.

    * individual results may vary

    1 to 6 week dear brightly program

    Complete your skincare fitness routine

    Our Derma Five products are designed for your healthiest skin. Developed by dermatologists, each of these products work in conjunction with Night Shift for optimal skin health.