Night Shift Set
dear brightly cream
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night shift cream

Night Shift Set

Tailored Retinoid + Moisturizer

Tailored Tretinoin and Moisturizer Duo

$108  $101.00
First Time Trial 2-month supply

  • Initial Night Shift bottle lasts around 2 months. Refills last around 3 months, billed at $141 per quarter. Adjust frequency or cancel at any time.
  • Bonus healing ingredient: Niacinamide, an anti-inflammatory agent that soothes redness and enhances hydration.
  • Bundled with our moisturizer specifically formulated for use with Night Shift
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Night Shift combines tretinoin, a highly efficacious prescription retinoid, with soothing, hydrating elements to revolutionize your nightly skincare regimen. With the powerful effects of tretinoin and niacinamide combined, our tailored formula caters to your specific skin needs. Plus, its luxurious texture pampers your skin with each use.

Due to the potential for retinoids to cause dryness or flakiness, it's crucial to have a specially formulated tretinoin and moisturizer duo. Developed in collaboration with board-certified dermatologists, we've crafted an incredibly smooth and hydrating companion to your personalized tretinoin prescription, available online. Daily Sip is a moisturizer to use with tretinoin designed for both morning and evening application, providing nourishment to your skin before, after, and between Night Shift treatments.

We don’t subscribe to the anti-aging mindset. Aging is a privilege, and we’re here to do it better than ever. When you feel good in your own skin, there’s nothing you can’t do. And when you accept that aging is living, your confidence will shine from the inside out.

Your tretinoin prescription online helps prevent and address wrinkles, pigmentation issues, uneven skin tone, enlarged pores, and acne. Niacinamide, an anti-inflammatory healing compound, alleviates redness, minimizes the appearance of large pores, prevents moisture loss, enhances hydration, and brightens the skin. Together, they unveil your ultimate skin potential.

The right tretinoin and moisturizer combo makes all the difference. Formulated with five ceramides and hyaluronic acid, Daily Sip works to reinforce the skin barrier, priming it to tolerate more powerful treatments such as retinoids. These moisturizing components not only enhance the efficacy of tretinoin but also work with exfoliators, other retinoid therapies, and tough environmental conditions.

You can be confident this tretinoin and moisturizer duo is cruelty-free, paraben-free, hypoallergenic, non-irritating, phthalate-free, and alcohol-free, with no added fragrances. Our reusable and eco-friendly glass bottle incorporates an airless tube mechanism, ensuring minimal oxidation and optimal stability.

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The Power of Retinoids


Retinoid stimulates the production of collagen, softening the appearance of fine lines and wrinkles. They also boost new blood vessels, which can give you a youthful rosy glow.


Yes! Retinoids clear cellular debris around enlarged pores, making them appear smaller and keeping them cleaner.


Retinoids are a first-line defense for treating and preventing blackheads as they decrease comedones and their precursor, thereby decreasing non inflammatory and inflammatory acne.


Tough acne that hasn’t responded to your usual treatments may respond well to a topical tretinoin prescription online. Retinoids unclog pores, which means your skin will absorb creams more efficiently.


Since topical retinoids exfoliate the skin, they definitely aid in the natural elimination of milia. It also iImproves roughness by reducing the layer of dead skin cells and increasing glycosaminoglycan (GAG).

Sun and Dark Spots

While not a cure-all for every type of hyperpigmentation, anti-inflammatory topical retinoids can improve pigmentation of freckles, melasma, sun spots and dark spots by dispersing melanin granules.



Your online Tretinoin prescription strength will vary between 0.015% and 0.089% based on your skin profile assessment.

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A soothing anti-inflammatory compound that reduces redness and enhances hydration.

Base: ST-Elastomer 10, Q7-9120 Silicone Fluid, EL-7040 Hydro Elastomer Blend, Vitamin E Acetate, Liquid, Polyglycerol-3 Diisostearique

All products are cruelty-free, paraben-free, mineral oil-free, and vegan.

Cruelty Free

Paraben Free

Fragrance Free

Alcohol Free

You might be asking yourself, “can I use tretinoin every night?” The answer? It depends. If you are new to retinoids, you should start with using tretinoin every third night then increase overtime as your skin’s tolerance builds. If your skin is responding well after this introductory period, you can start using tretinoin every night. The more frequently and consistently you use it, the greater the results. Always consult your dermatologist if you aren’t sure about your application frequency. (You can connect with your provider directly on your user dashboard!)

It’s always best to take caution when using potent acne treatments at the same time. We recommend you speak with your dermatologist before combining salicylic acid and tretinoin in your daily skincare routine, especially if you have sensitive and/or dry skin. Generally speaking, it is safe to use both, as long as you introduce them gradually and monitor your skin’s response.


Receive your tailored formula from our dermatologist partners to match your individual skin profile. Gentle and suitable even for the most sensitive skin types.

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Step 1

Tell us about your skin aspirations.

You can skip the in-person visit to the dermatologist. Simply provide details about your skin and upload photos on our secure telehealth portal within a few minutes.

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Step 2

Derms customize your formulation.

A doctor will carefully review your profile and tailor your online Tretinoin prescription, crafting a formula specifically for your needs.

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Step 3

Stay connected with your provider.

Similar to a fitness regimen, retinoids yield optimal results when introduced gradually. Your provider is accessible at all times to monitor your progress and provide guidance.

Take on the Night Shift

Here’s your Dear Brightly guide to tretinoin. Designed for nighttime use only – let us do the heavy lifting while you rest up. Use both tretinoin and moisturizer consistently for optimal results. 

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1. Cleanse

Cleanse your face with a mild cleanser, then gently pat dry with a towel. Ensure it is completely dry.

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2. Treat with Night Shift

Apply a dime-sized amount evenly over your face and neck (optional). Begin by using every third night, then gradually applying tretinoin every night as tolerated. Pay attention to your skin's response; it knows what's best.

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3. Moisturize

Complete your routine with your favorite moisturizer, Daily Sip, specifically crafted to complement your online Tretinoin prescription and included in this bundle set.

Night Shift For Anyone And Everyone


Certified physicians will familiarize themselves with your skin and begin your treatment with an appropriate strength level. As your skin adapts, they will adjust the strength accordingly. Our dermatologist partners customize your online Tretinoin prescription, ensuring a fantastic retinoid experience whether you're new to retinoids or an experienced user.

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Do you have sensitive or dry skin?

After assessing your skin, certified physicians can improve your skincare journey with customized retinoids. Whether your skin is sensitive or resilient, whether you're new to retinoids or not, they've got you covered. Recognizing the uniqueness of each skin type, they prescribe an appropriate strength level tailored to your specific needs. All of this ensures a fab retinoid experience as you progress.

Start seeing results as early as 2 weeks*

Progress comes with practice! Take it slow, stay patient, and witness the transformation of your skin. Building collagen takes time, which is why we've equipped you with the perfect routine for the journey. And remember, we're here to support you as your coach, teammate, and biggest fan.

* individual results may vary

1 to 6 week dear brightly program

Complete your skincare fitness routine

Crafted by dermatologists, our Derma Five products are formulated to promote your skin's health. Each product complements Night Shift, working together to enhance your skin's well-being.