Night Shift
Rx Face Serum

Tailored Tretinoin

$66 Trial Offer

Trial offer 2-month supply
Free Shipping

220 + Reviews

200+ Reviews

Prescription strength retinoid online

Tailored formula with Tretinon and Niacinimide

Formulated by board-certified dermatologists

Clinically proven to treat fine lines, wrinkles, pigmentation, uneven skin tone, enlarged pores, and acne.

Enjoy the ease of getting a prescription all online with no visit to the doctor’s office

Complete your skin profile, upload some photos and a doctor will review and tailor your formula just for you

First time bottle lasts ~2 months and refills last ~ 3 months and bill at $99/quarter

Change frequency or cancel any time

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*At checkout, answer questions and upload photos of your skin for your provider to determine if a prescription is appropriate.

Tretinoin Face Prescription Online

First-time bottle lasts ~2 months. Refills last ~3 months and bill at $99/quarter. Change frequency or cancel anytime.

Enjoy the ease of an online dermatologist review and get your Tretinoin, a prescription strength retinoid online.

Bonus ingredient: Niacinamide, an anti-inflammatory healing compound that calms redness and boosts hydration.

Description

AGING IS LIVING™

Anti-aging doesn't exist in our dictionary. We're pro-aging and here to do it better than ever. When you're comfortable in your skin, you're more confident in yourself. And when you're confident in yourself, you embrace that aging is living - a belief that shines from the skinside out. Get your tailored Tretinoin prescription online today.

GET TO KNOW NIGHT SHIFT

Night Shift is formulated with a powerful blend of Tretinoin, a prescription strength retinoid, and gentle, hydrating ingredients to transform your nightly skincare routine. Harnessing the dynamic duo of Tretinoin and Niacinamide, our tailored formula from skin experts is made for your unique skin. Our silky-smooth texture indulges your skin with every application.

TRETINOIN SERUM + NIACINAMIDE BENEFITS

Trust the science. Your Tretinoin prescription online is proven to prevent and treat wrinkles, pigmentation, uneven skin tone, enlarged pores, and acne. Its redness-reducing anti-inflammatory partner, niacinamide, reduces the appearance of big pores, prevents moisture loss and dehydration, and brightens the skin. Like every perfect match, they work together to reveal your best skin ever.

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Before & After

*Individual results may vary

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Community Reviews

				Perimenopause Skin Fix! Perimenopause hit my skin as if I was 15 again—- and working 3 weeks, my acne has calmed, my skin is softer, it feels so much healthier too. I also love the feeling of putting the cream on at night (I still use the sandwich method with DailySip). Thrilled with this product!
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Vanessa
6/13/2024
				Loving the Night Shift  I have been using Night Shift for 3 months now. I can really tell a difference in my skin. It looks healthier and I have gotten lots of comments about how good my skin looks. I am not experiencing any peeling or redness from using it and I am able to use it every night. I would highly recommend giving Night Shift a try if you are looking to amp up your skincare routine.
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Andrea
3/17/2024
				I started using this... I started using this product amid a horrible breakout on my cheeks. It took about three months to notice a difference since my skin tends to be very sensitive and I had to dip my toes in the water beforehand. I'm now up to three days a week and my skin continues to show weekly improvement. I'm glad I took the chance.
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Hillary
3/15/2024
				Such an amazing product!!! I’m 53 years old and this product has changed the appearance of my skin ten-fold. I have a skin tint and a little blush on in this pic. It has helped even my skin tone dramatically. My skin is glowing!
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Michelle
3/15/2024
				I started Night Shift and have experienced improvement I started Night Shift a few months ago. It took approximately 30 days to start seeing improvement in my skin but once it did I noticed less fine lines and a smoother appearance overall in my skin. I started my second bottle that has an increased RX percentage. I now have more dryness and flakeyness but I have since decreased how often I use it during the week. I believe the dryness and flakeyness is due to the change in season. My skin is sensitive and when seasons change my skin tends to dry out. I have significant sun damange discoloration and I feel the product has helped some to improve discoloration and tone. I will continue with the RX process. I am pleased.
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Christine
3/15/2024
				Dear Brightly is amazing The order process for this product was so easy.  The dermatologist was very easy to work with and I was 100% satisfied. Enjoy using this product and its ingredients leave my skin looking so healthy and not irritated or peeling like other retinoids I have used. It also allows you with ease to delay an order shipment if you do not need more product at the moment. Thank you guys!!
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Janet
3/15/2024
				Amazing Customer Service! I have only been using Night Shift for 2 weeks and I'm already seeing an improvement in my skin (sensitive with rosacea)! That's not why I'm writing a review (though I am excited to see what continued use will do for me). I have just been so impressed by the whole experience - the rx process is easy but thorough, and the dermatologist gave me such thoughtful responses to the concerns I noted during that process. I also reached out to customer service when I had a question and received a personalized video response walking me through the answer to my question. Best customer service I've had in a long time and I can't wait to try the rest of the products!
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Alexis
2/27/2024
				Highly recommend  Thanks to Dear Brightly, my skin feels smoother, plumper, and more supple. In three weeks, I noticed less dryness and fine lines and a more even appearance. Plus, the process couldn’t have been easier. I am so glad I signed up. No other skin care has given me these results.
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Liz
12/19/2023
				Love it  Definitely see a difference. Also my adult acne has much improved, and even more since the addition of niacinamide. My aging sun damage discoloration has almost disappeared.
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Cara
10/04/2023

As easy as 1-2-3.

Get a tailored solution from our dermatologist partners to match your unique skin profile – gentle enough for even the most sensitive skin.

STEP 1

Share your skin goals

No need for an in-person visit to the
dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.

STEP 2

Our doctors tailor your formula

You are unique and your skin is too. A doctor will review your profile and tailor your derm-strength Night Shift serum to create a formula just for you.

STEP 3

Check in with your skin coach

Like any fitness routine, retinoids work best by starting out slowly. Your provider is available at any time to check in and assess your progress.

ADD TO CART

Ingredients

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Tretinoin

This topical retinoid helps the skin by removing dead layers of skin and unclogging pores. Depending on your skin profile evaluation, your online Tretinoin prescription strengths can range from 0.015% to .089%

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Niacinamide

Also called nicotinamide, this anti-aging NSAID is a form of B3 found in many common foods. It’s required for well functioning fats and sugars in the body and the maintenance of healthy cells.

Click to see full ingredients list

Base: ST-Elastomer 10, Q7-9120 Silicone Fluid, EL-7040 Hydro Elastomer Blend, Vitamin E Acetate, Liquid, Polyglycerol-3 Diisostearique

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ALCHOHOL FREE

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CRUELTY FREE

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FRAGRANCE FREE

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PARABEN FREE

Night Shift for anyone and everyone.

Whether you have sensitive or dry skin, or whether you’re a retinoid rookie or not, our Board-certified doctors got you. Understanding that everyone's skin is different, they provide you with an appropriate strength of our tailored Tretinoin prescription for your specific skin type.

When your skin is ready, they’ll even upgrade your strength. At Dear Brightly we are committed to giving you a better overall retinoid experience.

ADD TO CART

Three women with their faces close together who use Dear Brightly's Night Shift

Start seeing results as early as 2 weeks.*

Practice makes progress! Start slowly, be patient, and watch your skin transform. Collagen isn’t built in a day, so we’ve made sure you’ve got the right routine for the journey. And we’re here to be your coach, teammate, and biggest fan – every step of the way.

*Individual results may vary

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1-2 weeks

Brightens and reduces uneven skin tone.

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2-4 weeks

Discoloration is improved.

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4-6 weeks

Brown spots diminish.

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3-6 months

Reduced fine lines and wrinkles.

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6 months - 1 year

Clear, radiant skin

The Power of Rx Retinoids.

Do retinoids help with wrinkles?

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Retinoid stimulates the production of collagen, softening the appearance of fine lines and wrinkles. They also boost new blood vessels, which can give you a youthful rosy glow.

Do retinoids help with large pores?

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Yes! Retinoids clear cellular debris around enlarged pores, making them appear smaller and keeping them cleaner.

Do retinoids help with blackheads?

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Retinoids are a first-line defense for treating and preventing blackheads as they decrease comedones and their precursor, thereby decreasing non inflammatory and inflammatory acne.

Do retinoids help with acne?

Tough acne that hasn’t responded to your usual treatments may respond well to a topical tretinoin prescription online. Retinoids unclog pores, which means your skin will absorb creams more efficiently.

Do retinoids help with milia and roughness?

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Since topical retinoids exfoliate the skin, they definitely aid in the natural elimination of milia. It also iImproves roughness by reducing the layer of dead skin cells and increasing glycosaminoglycan (GAG).

Do retinoids help with hyperpigmentation?

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While not a cure-all for every type of hyperpigmentation, anti-inflammatory topical retinoids can improve pigmentation of freckles, melasma, sun spots and dark spots by dispersing melanin granules.

Complete your skincare fitness routine.

Our Derma Five products are designed for your healthiest skin. Developed by dermatologists, each of these products work in conjunction with Night Shift Rx Face Serum for optimal skin health.