Night Shift is your custom-compounded Tretinoin formula, designed by dermatologists and delivered directly to you—without the hassle of appointments or pharmacy lines. But it’s more than just a prescription.
It’s a reimagining of what prescription skincare can feel like.
Instead of the sticky, chalky textures found in generic Tretinoin creams, Night Shift uses a proprietary, nourishing base that feels like a luxury serum and absorbs instantly.
Instead of a “one-size-fits-all” tube, you get a formula tailored to your skin’s needs, concerns, and tolerance.
Instead of harsh side effects, Night Shift includes calming ingredients that soothe irritation, making it ideal even for sensitive skin.
Night Shift is not a compromise between luxury and efficacy—it’s the first time you can have both.
Perimenopause Skin Fix! Perimenopause hit my skin as if I was 15 again—- and working 3 weeks, my acne has calmed, my skin is softer, it feels so much healthier too. I also love the feeling of putting the cream on at night (I still use the sandwich method with DailySip). Thrilled with this product!
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Vanessa Ford
6/13/2024
Loving the Night Shift I have been using Night Shift for 3 months now. I can really tell a difference in my skin. It looks healthier and I have gotten lots of comments about how good my skin looks. I am not experiencing any peeling or redness from using it and I am able to use it every night. I would highly recommend giving Night Shift a try if you are looking to amp up your skincare routine.
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Andrea Williams
3/17/2024
I started using this... I started using this product amid a horrible breakout on my cheeks. It took about three months to notice a difference since my skin tends to be very sensitive and I had to dip my toes in the water beforehand. I'm now up to three days a week and my skin continues to show weekly improvement. I'm glad I took the chance.
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Hillary
3/15/2024
Such an amazing product!!! I’m 53 years old and this product has changed the appearance of my skin ten-fold. I have a skin tint and a little blush on in this pic. It has helped even my skin tone dramatically. My skin is glowing!
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Michelle Stewart
3/15/2024
I started Night Shift and have experienced improvement I started Night Shift a few months ago. It took approximately 30 days to start seeing improvement in my skin but once it did I noticed less fine lines and a smoother appearance overall in my skin. I started my second bottle that has an increased RX percentage. I now have more dryness and flakeyness but I have since decreased how often I use it during the week. I believe the dryness and flakeyness is due to the change in season. My skin is sensitive and when seasons change my skin tends to dry out. I have significant sun damange discoloration and I feel the product has helped some to improve discoloration and tone. I will continue with the RX process. I am pleased.
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Christine Hoover
3/15/2024
Dear Brightly is amazing The order process for this product was so easy. The dermatologist was very easy to work with and I was 100% satisfied. Enjoy using this product and its ingredients leave my skin looking so healthy and not irritated or peeling like other retinoids I have used. It also allows you with ease to delay an order shipment if you do not need more product at the moment. Thank you guys!!
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Janet Ferrino
3/15/2024
Amazing Customer Service! I have only been using Night Shift for 2 weeks and I'm already seeing an improvement in my skin (sensitive with rosacea)! That's not why I'm writing a review (though I am excited to see what continued use will do for me). I have just been so impressed by the whole experience - the rx process is easy but thorough, and the dermatologist gave me such thoughtful responses to the concerns I noted during that process. I also reached out to customer service when I had a question and received a personalized video response walking me through the answer to my question. Best customer service I've had in a long time and I can't wait to try the rest of the products!
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Alexis
2/27/2024
Highly recommend Thanks to Dear Brightly, my skin feels smoother, plumper, and more supple. In three weeks, I noticed less dryness and fine lines and a more even appearance. Plus, the process couldn’t have been easier. I am so glad I signed up. No other skin care has given me these results.
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Liz Bazar
12/19/2023
Love it Definitely see a difference. Also my adult acne has much improved, and even more since the addition of niacinamide. My aging sun damage discoloration has almost disappeared.
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Cara
10/04/2023
Don’t Miss Out, This Offer Won’t Last Long
Skincare that actually works and feels good? That’s rare. So is this offer. Purchase now to receive:
Get a tailored solution from our dermatologist partners to match your unique skin profile – gentle enough for even the most sensitive skin.
STEP 1
Share your skin goals
No need for an in-person visit to the dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.
STEP 2
Our doctors tailor your formula
You are unique and your skin is too. A doctor will review your profile and tailor your derm-strength Night Shift serum to create a formula just for you.
STEP 3
Check in with your skin coach
Like any fitness routine, retinoids work best by starting out slowly. Your provider is available at any time to check in and assess your progress.
"I’ve used retinol for months and barely saw a difference—why would this be any better?"
In the world of skincare, you’ve been led to believe that results come from drugstore creams and influencer-endorsed serums. It’s not your fault those didn’t work—they were never strong enough to begin with.
Night Shift uses prescription-strength Tretinoin, the FDA-approved gold standard that’s 20x more powerful than retinol, combined with soothing ingredients that make it surprisingly gentle. You don’t need to keep guessing, you just need the right formula.
"Isn’t Tretinoin known for making your skin red and flaky?"
We get it, Tretinoin has a reputation. But it’s not the ingredient that’s the problem, it’s the outdated formulas and one-size-fits-all dosing. Night Shift was designed to change that.
With a nourishing base and a custom-compounded strength selected just for your skin, our formula delivers real results without the painful side effects. It’s not your skin that’s sensitive, it’s the wrong delivery system.
"I don’t have time for another 5-step skincare routine every night."
The beauty industry told you that more steps equal better skin. It’s not true. What you actually need is fewer steps with more science behind them. Night Shift replaces your serum, treatment, and night cream in one powerful step.
Just apply, rest, and let the formula work while you sleep. Simplicity isn’t a shortcut—it’s what finally makes consistency (and glowing skin) possible.
I've been using Night Shift for about 8 months and have noticed a big difference in my skin. It feels smoother and I break out less often. I did have some irritation in the beginning but that has largely ended. I love it. - Lauren W.
Been using for over a year now and have noticed a tremendous difference in my skin. I used to struggle with a bumpy forehead but now it’s smooth! Great addition to my skincare.
- Hilary L.
I love this product! It is so convenient to have it delivered and not have to struggle to get an in person appointment with a dermatologist!
- Kirstin K.
I love Dear Brightly products. I have stuck with them longer than any other product I’ve tried, and I really appreciate the ease of the subscription and the communication with the Dear Brightly team. Highly recommend!
- Victoria S.
Best decision I have made. Even my esthetician can’t believe how good my skin looks. My coworkers thought I used Botox. I recommend Night Shift to everyone.
- Heather B.
I feel like I haven't aged a day since I started using Night Shift. I can't wait to see the development over the years to come.
- Sally S.
The power of retinoids.
Retinoid stimulates the production of collagen, softening the appearance of fine lines and wrinkles. They also boost new blood vessels, which can give you a youthful rosy glow.
Yes! Retinoids clear cellular debris around enlarged pores, making them appear smaller and keeping them cleaner.
Retinoids are a first-line defense for treating and preventing blackheads as they decrease comedones and their precursor, thereby decreasing non inflammatory and inflammatory acne.
Tough acne that hasn’t responded to your usual treatments may respond well to a topical tretinoin prescription online. Retinoids unclog pores, which means your skin will absorb creams more efficiently.
Since topical retinoids exfoliate the skin, they definitely aid in the natural elimination of milia. It also iImproves roughness by reducing the layer of dead skin cells and increasing glycosaminoglycan (GAG).
While not a cure-all for every type of hyperpigmentation, anti-inflammatory topical retinoids can improve pigmentation of freckles, melasma, sun spots and dark spots by dispersing melanin granules.
You’ve done the trial-and-error. You’ve bought the hype. Now it’s time for what actually works. Night Shift is backed by science, customized by dermatologists, and delivered to your door.